Endocrine Abstracts

NR5A1, a member of the nuclear receptor superfamily, is a key transcriptional regulator of genes involved in the hypothalamic–pituitary–gonadal steroidogenic axis. Newborn mice deficient in NR5A1 lack both gonads and adrenal glands and have impaired expression of pituitary gonadotrophins. NR5A1 is expressed in foetal and adult Sertoli and Leydig cells of testis. NR5A1 is also expressed in multiple cell types in the foetal, postnatal, prepu...